Endoplasmic Reticulum-Associated Degradation (ERAD) -
a physiological process, which our bodies already have, is the key to reversing Type 2 Diabetes
ERAD is an essential cellular survival mechanism that handles problematic proteins in our bodies. Well-known problematic proteins that cause diseases include β-amyloid, misfolded insulin (as proinsulin), alpha-synuclein and, etc.. Like that misfolded β-amyloid causes Alzheimer's Disease, accumulation of misfolded insulin in the Endoplasmic Reticulum (ER) results in ER Stress, which consequently kills pancreatic β cells by initiating apoptosis. In fact, ER stress has been recognized as the top leading cause of β cell death.
ERAD can specifically target misfolded or unfolded proteins such as insulin for degradation. As ERAD can eliminate the cause of ER Stress, it has been considered a therapeutic target for many diseases.
In this accompanying video, you have found information regarding how ER stress and ERAD affect the progression of type II diabetes in more detail. We hope you will find this video helpful.