ERAD Plus
Helping Cells Stay Capable
as We Age
Aging Shows Up as Loss of Function
We recognize aging by what our bodies can no longer do as well as before.
Blood Sugar Regulation
β-cells become less capable of producing and releasing insulin.
Cognition & Memory
Brain cells become less effective at supporting
clear thinking and memory.
Muscle & Mobility
Muscle cells gradually lose strength, energy,
and recovery capacity.
Different organs may age differently, but many age-related changes share something in common:
They are gradually losing the ability to function as they once did.
But Why?
Why Does Aging Happen Gradually?
Aging doesn't happen overnight.
It develops slowly as tiny errors accumulate inside our cells over many years.
Imagine a factory where defective products keep piling up on the assembly line. Eventually, production slows down, workers become overwhelmed, and the factory can no longer operate efficiently.
As these problems accumulate, they can place increasing stress on the endoplasmic reticulum (ER)—a condition known as ER stress.
Persistent ER stress makes it harder for cells
to produce proteins, generate energy,
repair damage, and perform their normal jobs.
Over time, cells gradually lose function
—and that is one of the fundamental processes of biological aging.
References:
ERAD: The Cell's Natural Defense Against Aging
-ERAD helps cells remove misfolded proteins that contribute to ER Stress and cellular aging.
Every cell in our body contains a natural quality-control system called Endoplasmic Reticulum-Associated Degradation (ERAD). ERAD continuously identifies and removes misfolded proteins to reduce the ER stress that contributes to cellular aging.
Think of it as part of the cell's internal
quality-control and cleanup system.
When ERAD works efficiently, cells are
better equipped to maintain protein balance
and normal function.
As we age, however, the demands placed on
this system can increase.
This is where our research begins.
References:
1. Mechanisms of substrate processing during ER-associated protein degradation. Nature Reviews Molecular Cell Biology. 2023;24:777–796.
We Didn't Start With Ingredients.
We Started With a Cellular Target.
ERAD Plus grew out of research at Servo BioLabs focused on protein misfolding, cellular stress, and ERAD.
Instead of beginning with a list of popular herbs and asking what they might do, our research takes the opposite approach:
Identify the biological problem.
↓
Study the cellular pathway involved.
↓
Search for compounds that influence that pathway.
↓
Develop practical nutritional applications.
Our research program has focused on identifying naturally derived compounds that influence ERAD-related cellular processes in experimental systems.
This science-led approach became the foundation of ERAD Plus.
From Cellular Science to Everyday Health
ERAD is involved in many types of cells throughout the body.
That allows us to study how supporting cellular protein quality control may be relevant to different aspects of healthy aging.
Blood Sugar & β-Cell Health
Healthy blood sugar regulation depends not only on insulin sensitivity, but also on pancreatic β-cells that remain capable of producing insulin when the body needs it.
ERAD Plus Pre-D was developed with a different goal from conventional blood sugar supplements:
Don't just focus on the blood sugar number.
Support the cells behind the number.
Cognition & Memory
Protein quality control is also important in the brain.
Our ongoing research is exploring naturally derived ERAD modulators and related cellular pathways that may help support healthy brain function, cognition, and memory as we age.
References:
1. Endoplasmic Reticulum-Associated Degradation (ERAD) Has a Critical Role in Supporting Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells. Diabetes. 2019;68(4):733–746
Aging Is Inevitable.
How Fast We Lose Function May Not Be.
Every cell contains ERAD, a built-in quality-control system that continuously removes misfolded proteins and reduces ER stress associated with cellular aging.
Rather than altering or inhibiting normal biological function, the goal is to support and strengthen one of the body's fundamental protective mechanisms.
We believe healthier aging begins by helping cells stay capable of doing what they were designed to do.
That is the idea behind ERAD.
And the science behind ERAD Plus.